The track, a remake of Knopfler's own tune, which appeared in the 1983 film Local Hero, features over 60 guest artists billed as Mark Knopfler's Guitar Heroes, including the late Jeff Beck in his final recording before his January 2023 death.
The single features cover art designed by Sir Peter Blake, known for his work on The Beatles' Sgt. Pepper's Lonely Hearts Club Band, two The Who albums and more.
You can listen to "Going Home (Theme From Local Hero)" now via digital outlets and YouTube.
Knopfler's also set to drop the new album, One Deep River, on April 12. The album is available for preorder now.